(Lipo)polysaccharide interactions of antimicrobial peptides
نویسندگان
چکیده
منابع مشابه
Title Resurrecting Inactive Antimicrobial Peptides from the Lipopolysaccharide Trap Resurrecting Inactive Antimicrobial Peptides from Lipopolysaccharide (lps) Trap Singapore 637551, Singapore
26 Host defense antimicrobial peptides (AMPs) are a promising source of antibiotics for the 27 treatment of multiple drug-resistant pathogens. Lipopolysaccharide (LPS), the major 28 component of the outer leaflet of the outer membrane of Gram-negative bacteria, functions as 29 a permeability barrier against a variety of molecules including antimicrobial peptides (AMPs). 30 Further, LPS or endot...
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Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activities and specific antimicrobial mechanism. Besides broad-spectrum antibacteri...
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A single animal can express several cationic antimicrobial peptides with different sequences and structures. We demonstrate that mammalian peptides from different structural classes frequently show synergy with each other and selectively show synergy with human lysozyme.
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Biofilms of Pseudomonas aeruginosa are responsible for chronic lung infections in cystic fibrosis patients, where they are characterized by overproduction of the exopolysaccharide alginate and are recalcitrant to treatment with conventional antibiotics. Cationic antimicrobial peptides (CAPs) are potential alternatives for the treatment of multi-drug-resistant P. aeruginosa. However, alginate in...
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ژورنال
عنوان ژورنال: Journal of Colloid and Interface Science
سال: 2015
ISSN: 0021-9797
DOI: 10.1016/j.jcis.2014.11.024